GHRP-6 is a peptide that is found in the growth factor family, causing a strong release of hormone when it is present in an animal’s body. This peptide is largely used to stimulate hunger, in order to promote food intake and improving the energy of the metabolism.
This is a relatively new peptide and so much is still being learned about GHRP-6 and its functions, as well as whether or not synthetic versions of this peptide alter in function from the original chemical. Researchers believe that GHRP-6 will have a place in the future in treating deficiencies of hormone, obesity, eating disorders or cachexia.
Animals that are exposed to GHRP-6 are seen to have a significantly increased appetite because this peptide stimulates ghrelin in the body. Ghrelin is a natural peptide released by the stomach lining, to encourage gastric emptying and promoting the feeling of hunger.
GHRP-6 will also stimulate the pituitary gland which will cause hormone to be released. The peptide acts directly on the feedback loop, so a large portion of GHRP-6 in the system will inhibit the stimulation of hormone over time. GHRP-6 is also used to protect neurons in the central nervous system by increasing their strength, similar to the functions of dihydrotestosterone.
Hormone Secretion in Female Rats
Age has been associated with limiting the effects of hormone on animals so this experiment moved to determine how the effects of aging would stand up to the administration of GHRP-6.
GHRP-6 was applied on its own or along with GHRH in different test groups of anesthetized female rats. These rats were between 3 and 19 months of age.
The peptides that were administered simultaneously were designed to see the effects of how GHRP-6 and GHRH work together.
An increase of plasma hormone function over time was lower with administrations of GHRP-6 in older rats rather than young rats. The increase in the function of hormone in the plasma was higher for older rats that had the combination of peptides administered.
Pituitary secretions of hormone in the older rats were generally lower than those in the younger rats, with results suggesting that hormone function acts as a reserve in old female rats and this peptide is not associated with regular function.
This data also suggests that the cellular processes used to secrete hormone when stimulated remain intact in older rats. Age-related decrements of the secretion of hormone seem to stem from an inadequate amount of stimulation rather than alterations to the function of this mechanism.
Comparing GHRP-6 to GHRP-2
Studies of GHRP-2 on the release of hormones were evaluated, using the pituitary cells of rats and these results were compared to those standards for GHRP-6.
In rats GHRP-2 and GHRP-6 both act synergistically alongside GRF to release hormone.
Administering GHRP-2 alongside GHRP-6 at the maximum concentration for these peptides did not see an improvement on the release of hormone, compared to when these chemicals were released on their own.
The GHRP chemicals did not desensitize each other or GRF.
The effects of GHRP-2 were inhibited by another peptide antagonist, which concluded that this peptide can stimulate the pituitary gland to release hormone, in a similar way to GHRP-6, in spite of their structural differences.
If GHRP-6 is administered to an animal along with insulin it will further increase the body’s response to this peptide. Studies on mice show that the body’s muscle growth, body composition, memory, glucose metabolism and cardiac function can be improved by applying this peptide. Because this chemical is fairly new to the research setting, there is still much to be learned regarding the function of GHRP-6 and the chemical interactions that promote its function.
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